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| CAS:661472‑41‑9:Relamorelin | |
| Relamorelin is a new‑generation highly selective growth hormone secretagogue receptor 1a (GHSR‑1a) agonist. Amino acid site modifications significantly enhance enzymatic degradation resistance. It specifically binds to GHSR‑1a receptors, promotes growth hormone secretion, while enhancing gastric motility and accelerating gastric emptying, and regulates appetite and energy metabolism. Applied in mechanism research of diabetic gastroparesis, functional dyspepsia, growth hormone deficiency and other diseases, as well as gastrointestinal motility peptide drug development. | |
| 95%/98%/99% | |
| ~3300 (free peptide, subject to actual synthetic batch) | |
| Function Tags (comma-separated) | ||||||||
| Relamorelin; RM-131; Ghrelin receptor agonist | Prokinetic,Growth hormone promotion,GHSR-1a agonism,Gastroparesis research,Appetite regulation,Gastrointestinal peptide | - | ~3300 (theoretical, free peptide) | ~28 |
| Long-term Storage Conditions | Short-term Storage Conditions | ||||
| PEP-REL003 | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Stable for 1 month at 2-8℃ sealed & dry; prepare aqueous solutions freshly before use | Stable for 72h at 4℃; stable for 1 month at -20℃ in aliquots. **Moderate water solubility, soluble in dilute acetic acid or acidic buffer**. DPP-IV resistance significantly improved, but still prone to endopeptidase degradation | Stable for 2 years at -20℃ under dry & dark conditions |
| Applicable Research Areas (comma-separated) | ||||
| PEP-REL003 | Highly selective GHSR-1a agonist that promotes gastric motility, accelerates gastric emptying and induces growth hormone secretion | Relamorelin binds to the G protein-coupled GHSR-1a receptor with high specificity and affinity, activates the downstream Gq/11-mediated PLC-IP3-Ca²⁺ signaling pathway, and exerts multiple biological effects: centrally, it acts on the pituitary to promote growth hormone synthesis and release; peripherally, it acts on gastrointestinal smooth muscle and the enteric nervous system, enhances antral contraction, coordinates gastroduodenal motility, accelerates gastric emptying, and improves gastroparesis symptoms. It also acts on the hypothalamic feeding center to regulate appetite and energy metabolism. Compared with native Ghrelin, its site modification avoids rapid enzymatic cleavage by DPP-IV, extending in vivo half-life by several folds with longer lasting effect. | Growth Hormone Secretagogue Receptor 1a (GHSR-1a); PLC-IP3-Ca²⁺ signaling pathway; Gastric motility regulation and growth hormone secretion pathway |
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